Our Team

Principal Investigator

  • headshot: amedee de georges

    Amédée des Georges, Ph.D.

    • Assistant Professor, Structural Biology Initiative
    • Assistant Professor of Chemistry and Biochemistry, The City College of New York
    Email: adesgeorges@gc.cuny.edu
    Phone: 212.413.3232

    Since his first class on the subject, Des Georges has been fascinated by protein structures and allosteric control. He found electron microscopy to be a compelling tool to study their function and dynamics, and he joined the Linda Amos lab for his Ph.D to learn its techniques. He subsequently joined the Joachim Frank lab to learn the single-particle technique during his postdoctoral studies.

    Still excited by its ability to visualize proteins directly, he continues to foray into the study of protein dynamics with cryo-electron microscopy, trying to learn as much as he can on the allosteric modulation of membrane proteins and on the role this plays in cell signaling. He enjoys exploring science with others, as a conversation in the pursuit of knowledge. He believes in fostering these conversations within his group to make science a fun and exciting pursuit.

    The des Georges lab studies structural and functional study of the regulation of large macromolecular complexes using cryo-electron microscopy.

Research Team

  • headshot: Emily Armbruster

    Emily Armbruster, Ph.D.

    • Postdoctoral Research Associate, des Georges Lab, Structural Biology
    Email: earmbruster@gc.cuny.edu

    Trained as a microscopist and biochemist, I use these skills to understanding how biomolecules move as they dance and stick together in their hot, crowded thermal bath. Before COVID Emily enjoyed team and endurance sports, but now she mostly re-watches old TV shows and tries to train her recently adopted Miniature Pinscher. As part of the des George lab she works to prepare, image, and process data using Single Particle Analysis Cryo-EM techniques to determine the structure of macromolecules in order to understand their involvement in cell signaling and maintenance.

  • Harsh Bansia, Ph.D.

    • Postdoctoral Research Associate, des Georges Lab, Structural Biology Initiative
    Email: hbansia@gc.cuny.edu

    To me, one of the fascinating and satisfying aspect of being a structural biologist is the everyday chance to also become a mathematician, physicist, chemist and a computer scientist. After being introduced to biological macromolecular machines and different levels at which they can be studied, I decided to explore the foundational level and joined IISc for my PhD to study protein structure, function and dynamics using X-ray crystallography and MD simulations. As a postdoc in Des Georges lab, I use cryo-EM and machine learning to experimentally capture protein dynamics going well beyond the “one structure describes it all” notion. As a structural biologist, my long-term goal is to study intrinsically disordered proteins. As they say in structural biology, intrinsic disorder is the limit.

  • Andres Cabezas

    • Doctoral Student, des Georges Lab, Structural Biology Initiative
    Email:

    I graduated in 2019 from New Jersey City University, the school where I gained valuable research experience in Dr. Yufeng Wei biochemistry lab and mentorship in classes from memorable faculty. I joined the des Georges lab to learn more about the amazing ability of cryo-electron microscopy to obtain snapshots of large proteins, such as calcium ion channels, and ultimately obtain high resolution structural models of them. My research focuses on protein-lipid interactions, as they play a major role in membrane protein function. Aside from lab work, I enjoy sports, gaming with friends, and improving my computer science skills.

  • headshot: da cui

    Da Cui

    • Doctoral Student, des Georges Lab, Structural Biology
    Email: dcui@gc.cuny.edu

    After getting a B.S. in Biochemistry and B.A. in mathematics from Hobart and William Smith Colleges, and two years of research at Tulane University, I joined des Georges’ lab in 2018 with a huge enthusiasm in applying the state-of-the-art technique of cryo-EM to solve the mechanisms of macromolecular assembly related to the Central Dogma. My long-term goal is to start my own lab in a research institute, contributing to the elucidation of key pathways related to cellular physiology with biophysical and biochemical tools, and training future students to continue the scientific development. Outside lab, I enjoy basketball, photography and backpacking. CMOS is one of my best friends now, both in the lab, and high in the remote mountains. 

  • headshot: dominique gutierrez

    Dominique Gutierrez

    • Doctoral Student, des Georges Lab, Structural Biology
    Email: dgutierrez@gc.cuny.edu

    As an undergrad research assistant at UTEP, fluorescently localizing viral-host protein interactions in the cellular pool made me interested in seeing such interactions more directly and in comprehending their novel  effects on cellular processes, such as translation. I got to explore this interest when I spent a summer in Joachim Frank’s cryo-EM ribosome lab in New York City.  Fascinated by the vast scientific community present in the city and Amedee des Georges’s cryo-EM expertise, I joined the ASRC for my graduate studies to learn single-particle cryo-EM. Mastering techniques from such an evolving field has been a very exciting challenge. My goal is to become an independent scientist whose research contributes to the physiological and mechanistic understanding of cellular complexes. 

  • headshot: tara marcink

    Tara Marcink, Ph.D.

    • Postdoctoral Research Associate, des Georges Lab, Structural Biology Initiative
    Email: tmarcink@gc.cuny.edu

    I obtained my Ph.D. in Biochemistry from the University of Missouri in 2018. My previous research focused on elucidating protein interactions between MT1-MMP, a key metastatic protein, and the cell surface, using various biochemical techniques including NMR, FRET, and electron microscopy to discover how this protein binds to nanodiscs. I continue pursuing my love of structural biochemistry through this unique collaboration between the des Georges Lab at CUNY and Anne Moscona’s and Matteo Porotto’s labs at Columbia University Medical Center where I try to uncover the structure and function of protein complexes involved in respiratory virus fusion with host cells using cry-electron tomography.
    Outside of the lab, I enjoy running, creating digital artwork, and making fancy desserts.

  • Jack Mechler

    • Doctoral Student, des Georges Lab, Structural Biology Initiative
    Email: jmechler@gradcenter.cuny.edu