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des Georges Lab

Publications

Research articles, reviews, and preprints from the lab and earlier collaborative work.

Current and former lab members, including visiting researchers, are shown in bold. Journal publications are listed from PubMed. Conference abstracts are omitted. Preprints are listed separately until a journal version is identified.

37 journal publications · 4 preprints

Preprints

bioRxiv

  1. Preprint

    Structural basis for direct NGF/TrkA blockade by an analgesic antibody

    Bansia H, Damo E, Glasser E, Bruni R, Koide S, Bunnett NW, des Georges A.

    bioRxiv · 2026

    bioRxiv

  2. Preprint

    Precision Aptamers Against a Native GPCR through Ligand-Guided Selection

    Egbe Vydaline AO, Bhate M, Sitaldin D, Cen YN, Rozhkov S, Sosa G, des Georges A, Mallikaratchy P.

    bioRxiv · 2026: 2026.05.04.722743

    PubMed bioRxiv Full text

  3. Preprint

    Structural basis of the lobster carapace blue colour mediated by an HPR protein

    Cedri MC, Bansia H, Amici A, Ortore MG, McCarthy A, Mueller-Dieckmann C, Lingas R, Durbeej B, Raffaelli N, Wang T, des Georges A, Cianci M.

    bioRxiv · 2026: 2026.02.26.708136

    PubMed bioRxiv Full text

  4. Preprint

    The translation initiation factor DHX29 appears to pull on mRNA in a direction opposite to scanning

    Cui D, Pestova T, Hellen C, des Georges A.

    bioRxiv · 2025: 2025.07.13.664561

    PubMed bioRxiv Full text

    PDB
    9CPA
    EMDB
    EMD-3057 (reused map)

Journal publications

2026

  1. Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

    Kim K, Li H, Yuan Q, Melville Z, Zalk R, des Georges A, Frank J, Hendrickson WA, Marks AR, Clarke OB.

    Nat Commun · 2026; 17(1): 10549

    PubMed Journal article Full text

    Structures & data · PDB (16) · EMDB (55) · EMPIAR (3)
    PDB
    9ZK89ZK99ZKA9ZKC9ZKD9ZKE9ZL79ZLC9ZLF9ZLH9ZN69ZN79ZN89ZN99ZNA9ZND
    EMDB
    EMD-74282EMD-74290EMD-74292EMD-74293EMD-74294EMD-74295EMD-74296EMD-74297EMD-74298EMD-74299EMD-74300EMD-74301EMD-74302EMD-74303EMD-74304EMD-74305EMD-74306EMD-74307EMD-74308EMD-74309EMD-74310EMD-74311EMD-74314EMD-74328EMD-74348EMD-74349EMD-74350EMD-74351EMD-74352EMD-74353EMD-74354EMD-74355EMD-74356EMD-74357EMD-74358EMD-74359EMD-74361EMD-74362EMD-74363EMD-74364EMD-74365EMD-74392EMD-74394EMD-74397EMD-74398EMD-74401EMD-74402EMD-74403EMD-74404EMD-74436EMD-74437EMD-74438EMD-74439EMD-74441EMD-74445
    EMPIAR
    EMPIAR-13733EMPIAR-13734EMPIAR-13770

  2. Sym024 Interacts with a Unique Epitope on the CD73 Homodimer, Favoring Effective Bivalent Binding to Improve Anti-PD-1 Therapy

    Jakobsen JS, Grandal MM, Hansen RW, Bansia H, Armbruster E, Theret I, Skartved NJØ, Hald R, Melander MC, Worsaae A, Riva M, Reckzeh K, Vuillard L, Lantto J, des Georges A, Fröhlich C.

    Clin Cancer Res · 2026; 32(6): 1120-1135

    PubMed Journal article Full text

    PDB
    9P1M
    EMDB
    EMD-71123EMD-71125EMD-71126EMD-71127EMD-71128

  3. Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy

    Pakharukova N, Thomas BN, Bansia H, Li L, Bassford DK, Abzalimov RR, Kim J, Kahsai AW, Pani B, Xiao K, Ochakovski R, Liu S, Zhang X, Ahn S, des Georges A, Lefkowitz RJ.

    Nat Commun · 2026; 17(1): 2973

    PubMed Journal article Full text

    PDB
    9BT89CX39CX9
    EMDB
    EMD-44881EMD-45977EMD-45982

  4. Sample purification and characterization of the α- and β-crustacyanin pigments from the American lobster for crystallographic and cryo-EM studies

    Cedri MC, Bansia H, Amici A, Collet T, Moretti P, McCarthy AA, Mueller-Dieckmann C, Raffaelli N, Wang T, des Georges A, Cianci M.

    Acta Crystallogr F Struct Biol Commun · 2026; 82(Pt 2): 49-56

    PubMed Journal article Full text

2025

  1. Pore formation by the CDTb component of the Clostridioides difficile binary toxin is Ca2+-dependent

    Abeyawardhane DL, Sevdalis SE, Adipietro KA, Godoy-Ruiz R, Varney KM, Nawaz IF, Spittel AX, Hunter D, Rustandi RR, Silin VI, des Georges A, Cook ME, Pozharski E, Weber DJ.

    Commun Biol · 2025; 8(1): 901

    PubMed Journal article Full text

    Structures & data · PDB (4) · EMDB (3)
    PDB
    8EKK8EKL8EKM9MUI
    EMDB
    EMD-28205EMD-28206EMD-28207
  2. Review

    Connecting the dots: deep learning-based automated model building methods in cryo-EM

    Bansia H, des Georges A.

    Front Mol Biosci · 2025; 12: 1613399

    PubMed Journal article Full text

2024

  1. Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models

    Peach CJ, Tonello R, Damo E, Gomez K, Calderon-Rivera A, Bruni R, Bansia H, Maile L, Manu AM, Hahn H, Thomsen AR, Schmidt BL, Davidson S, des Georges A, Khanna R, Bunnett NW.

    J Clin Invest · 2024; 135(4): e183873

    PubMed Journal article Full text

  2. Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells

    Fedry J, Silva J, Vanevic M, Fronik S, Mechulam Y, Schmitt E, des Georges A, Faller WJ, Förster F.

    Mol Cell · 2024; 84(6): 1078-1089.e4

    PubMed Journal article Full text

    Structures & data · EMDB (31)
    EMDB
    EMD-19211EMD-19212EMD-19213EMD-19214EMD-19215EMD-19216EMD-19217EMD-19218EMD-19219EMD-19220EMD-19221EMD-19222EMD-19223EMD-19224EMD-19225EMD-19226EMD-19227EMD-19228EMD-19229EMD-19230EMD-19231EMD-19232EMD-19233EMD-19234EMD-19235EMD-19236EMD-19237EMD-19238EMD-19239EMD-19240EMD-19241

2023

  1. Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster

    Lende SSF, Barnkob NM, Hansen RW, Bansia H, Vestergaard M, Rothemejer FH, Worsaae A, Brown D, Pedersen ML, Rahimic AHF, Juhl AK, Gjetting T, Østergaard L, des Georges A, Vuillard LM, Schleimann MH, Koefoed K, Tolstrup M.

    PLoS One · 2023; 18(9): e0291131

    PubMed Journal article Full text

  2. pH-tunable membrane-active polymers, NCMNP2a-x, and their potential membrane protein applications

    Trinh TKH, Cabezas AJ, Joshi S, Catalano C, Siddique AB, Qiu W, Deshmukh S, des Georges A, Guo Y.

    Chem Sci · 2023; 14(26): 7310-7326

    PubMed Journal article Full text

    PDB
    7RR67RR77RR8
    EMDB
    EMD-24653EMD-24654EMD-24655

  3. Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms

    Marcink TC, Zipursky G, Cheng W, Stearns K, Stenglein S, Golub K, Cohen F, Bovier F, Pfalmer D, Greninger AL, Porotto M, des Georges A, Moscona A.

    Sci Adv · 2023; 9(6): eade2727

    PubMed Journal article Full text

    EMDB
    EMD-27550EMD-27551
    EMPIAR
    EMPIAR-11103EMPIAR-11104

2022

  1. Intermediates in SARS-CoV-2 spike-mediated cell entry

    Marcink TC, Kicmal T, Armbruster E, Zhang Z, Zipursky G, Golub KL, Idris M, Khao J, Drew-Bear J, McGill G, Gallagher T, Porotto M, des Georges A, Moscona A.

    Sci Adv · 2022; 8(33): eabo3153

    PubMed Journal article Full text

    Structures & data · EMDB (7) · EMPIAR (1)
    EMDB
    EMD-24599EMD-24600EMD-24601EMD-24602EMD-24603EMD-24604EMD-26679
    EMPIAR
    EMPIAR-10788

  2. Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing

    Cheng EL, Cardle II, Kacherovsky N, Bansia H, Wang T, Zhou Y, Raman J, Yen A, Gutierrez D, Salipante SJ, des Georges A, Jensen MC, Pun SH.

    J Am Chem Soc · 2022; 144(30): 13851-13864

    PubMed Journal article Full text

    PDB
    7ZQS
    EMDB
    EMD-14874

2021

  1. Cryo-EM Structure of Mechanosensitive Channel YnaI Using SMA2000: Challenges and Opportunities

    Catalano C, Ben-Hail D, Qiu W, Blount P, des Georges A, Guo Y.

    Membranes (Basel) · 2021; 11(11): 849

    PubMed Journal article Full text

    PDB
    7N4T
    EMDB
    EMD-24177

  2. ENRICH: A fast method to improve the quality of flexible macromolecular reconstructions

    Kazemi M, Sorzano COS, Carazo JM, des Georges A, Abrishami V, Vargas J.

    Prog Biophys Mol Biol · 2021; 164: 92-100

    PubMed Journal article

2020

  1. Retrieving functional pathways of biomolecules from single-particle snapshots

    Dashti A, Mashayekhi G, Shekhar M, Ben Hail D, Salah S, Schwander P, des Georges A, Singharoy A, Frank J, Ourmazd A.

    Nat Commun · 2020; 11(1): 4734

    PubMed Journal article Full text

    Structures & data · PDB (6) · EMDB (6) · EMPIAR (1)
    PDB
    6PV67JMF7JMG7JMH7JMI7JMJ
    EMDB
    EMD-20486EMD-22392EMD-22393EMD-22394EMD-22395EMD-22396
    EMPIAR
    EMPIAR-10315

  2. Human parainfluenza virus fusion complex glycoproteins imaged in action on authentic viral surfaces

    Marcink TC, Wang T, des Georges A, Porotto M, Moscona A.

    PLoS Pathog · 2020; 16(9): e1008883

    PubMed Journal article Full text

    EMDB
    EMD-22334
    EMPIAR
    EMPIAR-10476

  3. Hijacking the Fusion Complex of Human Parainfluenza Virus as an Antiviral Strategy

    Marcink TC, Yariv E, Rybkina K, Más V, Bovier FT, des Georges A, Greninger AL, Alabi CA, Porotto M, Ben-Tal N, Moscona A.

    mBio · 2020; 11(1): e03203-19

    PubMed Journal article Full text

  4. Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a di-heptamer macromolecular assembly

    Xu X, Godoy-Ruiz R, Adipietro KA, Peralta C, Ben-Hail D, Varney KM, Cook ME, Roth BM, Wilder PT, Cleveland T, Grishaev A, Neu HM, Michel SLJ, Yu W, Beckett D, Rustandi RR, Lancaster C, Loughney JW, Kristopeit A, Christanti S, Olson JW, MacKerell AD, des Georges A, Pozharski E, Weber DJ.

    Proc Natl Acad Sci U S A · 2020; 117(2): 1049-1058

    PubMed Journal article Full text

    PDB
    6UWI6UWO6UWR6UWT
    EMDB
    EMD-20926EMD-20927

2019

  1. Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex

    Nguyen AH, Thomsen ARB, Cahill TJ, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ.

    Nat Struct Mol Biol · 2019; 26(12): 1123-1131

    PubMed Journal article Full text

    PDB
    6NI26NI3
    EMDB
    EMD-9375EMD-9376EMD-9377

  2. Cryo-EM structure of the human ferritin-transferrin receptor 1 complex

    Montemiglio LC, Testi C, Ceci P, Falvo E, Pitea M, Savino C, Arcovito A, Peruzzi G, Baiocco P, Mancia F, Boffi A, des Georges A, Vallone B.

    Nat Commun · 2019; 10(1): 1121

    PubMed Journal article Full text

    PDB
    6GSR6H5I
    EMDB
    EMD-0046EMD-0140

2018

  1. Mechanisms of opening and closing of the bacterial replicative helicase

    Chase J, Catalano A, Noble AJ, Eng ET, Olinares PD, Molloy K, Pakotiprapha D, Samuels M, Chait B, des Georges A, Jeruzalmi D.

    Elife · 2018; 7: e41140

    PubMed Journal article Full text

    PDB
    6BBM
    EMDB
    EMD-7076

  2. Engineered ferritin for lanthanide binding

    Calisti L, Trabuco MC, Boffi A, Testi C, Montemiglio LC, des Georges A, Benni I, Ilari A, Taciak B, Białasek M, Rygiel T, Król M, Baiocco P, Bonamore A.

    PLoS One · 2018; 13(8): e0201859

    PubMed Journal article Full text

    PDB
    5OBA5OBB

  3. Viral Entry Properties Required for Fitness in Humans Are Lost through Rapid Genomic Change during Viral Isolation

    Iketani S, Shean RC, Ferren M, Makhsous N, Aquino DB, des Georges A, Rima B, Mathieu C, Porotto M, Moscona A, Greninger AL.

    mBio · 2018; 9(4): e00898-18

    PubMed Journal article Full text

  4. Routine single particle CryoEM sample and grid characterization by tomography

    Noble AJ, Dandey VP, Wei H, Brasch J, Chase J, Acharya P, Tan YZ, Zhang Z, Kim LY, Scapin G, Rapp M, Eng ET, Rice WJ, Cheng A, Negro CJ, Shapiro L, Kwong PD, Jeruzalmi D, des Georges A, Potter CS, Carragher B.

    Elife · 2018; 7: e34257

    PubMed Journal article Full text

    Structures & data · EMDB (18) · EMPIAR (19)
    EMDB
    EMD-7135EMD-7138EMD-7139EMD-7140EMD-7141EMD-7142EMD-7143EMD-7144EMD-7145EMD-7146EMD-7147EMD-7148EMD-7149EMD-7150EMD-7151EMD-7152EMD-7153EMD-7154
    EMPIAR
    EMPIAR-10129EMPIAR-10130EMPIAR-10131EMPIAR-10132EMPIAR-10133EMPIAR-10134EMPIAR-10135EMPIAR-10136EMPIAR-10137EMPIAR-10138EMPIAR-10139EMPIAR-10140EMPIAR-10141EMPIAR-10142EMPIAR-10143EMPIAR-10144EMPIAR-10145EMPIAR-10187EMPIAR-10188
  5. Review

    Ryanodine Receptor Structure and Function in Health and Disease

    Santulli G, Lewis D, des Georges A, Marks AR, Frank J.

    Subcell Biochem · 2018; 87: 329-352

    PubMed Journal article Full text

2017

  1. Humanized archaeal ferritin as a tool for cell targeted delivery

    de Turris V, Cardoso Trabuco M, Peruzzi G, Boffi A, Testi C, Vallone B, Celeste Montemiglio L, des Georges A, Calisti L, Benni I, Bonamore A, Baiocco P.

    Nanoscale · 2017; 9(2): 647-655

    PubMed Journal article

    PDB
    5LS9

2016

  1. Structural Basis for Gating and Activation of RyR1

    des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J.

    Cell · 2016; 167(1): 145-157.e17

    PubMed Journal article Full text

    Structures & data · PDB (25) · EMDB (25)
    PDB
    5T155T9M5T9N5T9R5T9S5T9V5TA35TAL5TAM5TAN5TAP5TAQ5TAS5TAT5TAU5TAV5TAW5TAX5TAY5TAZ5TB05TB15TB25TB35TB4
    EMDB
    EMD-8342EMD-8372EMD-8373EMD-8374EMD-8375EMD-8376EMD-8377EMD-8378EMD-8379EMD-8380EMD-8381EMD-8382EMD-8383EMD-8384EMD-8385EMD-8386EMD-8387EMD-8388EMD-8389EMD-8390EMD-8391EMD-8392EMD-8393EMD-8394EMD-8395

2015

  1. Structure of mammalian eIF3 in the context of the 43S preinitiation complex

    des Georges A, Dhote V, Kuhn L, Hellen CU, Pestova TV, Frank J, Hashem Y.

    Nature · 2015; 525(7570): 491-5

    PubMed Journal article Full text

    PDB
    5A5T5A5U
    EMDB
    EMD-3056EMD-3057EMD-3058

  2. Structure of a mammalian ryanodine receptor

    Zalk R, Clarke OB, des Georges A, Grassucci RA, Reiken S, Mancia F, Hendrickson WA, Frank J, Marks AR.

    Nature · 2015; 517(7532): 44-9

    PubMed Journal article Full text

    PDB
    5TB0 (replaces 3J8E)
    EMDB
    EMD-6106

2014

  1. Structure of the mammalian ribosomal pre-termination complex associated with eRF1.eRF3.GDPNP

    des Georges A, Hashem Y, Unbehaun A, Grassucci RA, Taylor D, Hellen CU, Pestova TV, Frank J.

    Nucleic Acids Res · 2014; 42(5): 3409-18

    PubMed Journal article Full text

    PDB
    3J5Y
    EMDB
    EMD-5801

2013

  1. Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit

    Hashem Y, des Georges A, Dhote V, Langlois R, Liao HY, Grassucci RA, Pestova TV, Hellen CU, Frank J.

    Nature · 2013; 503(7477): 539-43

    PubMed Journal article Full text

    PDB
    4C4Q
    EMDB
    EMD-2450EMD-2451

  2. Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29

    Hashem Y, des Georges A, Dhote V, Langlois R, Liao HY, Grassucci RA, Hellen CU, Pestova TV, Frank J.

    Cell · 2013; 153(5): 1108-19

    PubMed Journal article Full text

    EMDB
    EMD-5658

  3. High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome

    Hashem Y, des Georges A, Fu J, Buss SN, Jossinet F, Jobe A, Zhang Q, Liao HY, Grassucci RA, Bajaj C, Westhof E, Madison-Antenucci S, Frank J.

    Nature · 2013; 494(7437): 385-9

    PubMed Journal article Full text

    PDB
    4V8M
    EMDB
    EMD-2239

  4. Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome

    Sharma G, Pallesen J, Das S, Grassucci R, Langlois R, Hampton CM, Kelly DF, des Georges A, Frank J.

    J Struct Biol · 2013; 181(2): 190-4

    PubMed Journal article Full text

2012

  1. Effect of envelope proteins on the mechanical properties of influenza virus

    Schaap IA, Eghiaian F, des Georges A, Veigel C.

    J Biol Chem · 2012; 287(49): 41078-88

    PubMed Journal article Full text

2008

  1. Mal3, the Schizosaccharomyces pombe homolog of EB1, changes the microtubule lattice

    des Georges A, Katsuki M, Drummond DR, Osei M, Cross RA, Amos LA.

    Nat Struct Mol Biol · 2008; 15(10): 1102-8

    PubMed Journal article Full text

Last checked October 19, 2026 · Download publication list